739. Middle East Respiratory Syndrome Coronavirus Infection Profile in Qatar: A 7-Year Retrospective Study
Identifieur interne : 000A99 ( Main/Exploration ); précédent : 000A98; suivant : 000B00739. Middle East Respiratory Syndrome Coronavirus Infection Profile in Qatar: A 7-Year Retrospective Study
Auteurs : Nada Elmaki [Qatar] ; Fatma Ben Abid [Qatar] ; Elmubasher Farag [Qatar] ; Hussam Alsoub [Qatar] ; Hafedh Ghazouani Ghazouani [Qatar] ; Mulham Mohed Saleh [Qatar] ; Khalid M. Dousa [États-Unis] ; Abdullatif Al-Khal [Qatar] ; Samar Mahmoud A. Hashim [Qatar] ; Muna Al- Maslamani [Qatar]Source :
- Open Forum Infectious Diseases [ 2328-8957 ] ; 2018.
Abstract
A deadly zoonotic
This was a retrospective-observational study of all laboratory confirmed cases of
The mean annual incidence was 1.7 per 100,0000 person-years. Among the 24 confirmed cases of of
The median symptoms duration was 4.5 days. Most of the patient presented with flu-like symptoms, were fever was the most common presentation, followed by cough, SOB, diarrhea, abdominal pain and headache, 96%, 83%, 33%, 8%, 8% and 4%, respectively. All patients were admitted to a tertiary hospital with a median hospital stay 41 days (8–97). Forty-five percent patients developed severe sepsis with multi-organ failure and needed ICU admission. Fifty percent patients developed acute kidney injury, 29% patients were on hemodialysis and 16% needed extra-corporeal membrane oxygenation. Thirty-three percent patients died. The rest of patients had recovered from the infection and discharged home. Among those who died all had one or more comorbidities.
Url:
DOI: 10.1093/ofid/ofy210.746
PubMed: NONE
PubMed Central: 6255065
Affiliations:
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Le document en format XML
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<author><name sortKey="Al Maslamani, Muna" sort="Al Maslamani, Muna" uniqKey="Al Maslamani M" first="Muna" last="Al- Maslamani">Muna Al- Maslamani</name>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec id="s1"><title>Background</title>
<p>A deadly zoonotic <italic>Middle East respiratory syndrome coronavirus</italic>
(<italic>MERS-CoV</italic>
) had emerged over the last 7 years in the Arabian Peninsula. As of February 28, 2018, 2,182 cases of <italic>MERS-CoV</italic>
infection (with 779 deaths) in 27 countries were reported to WHO worldwide. The objectives of this study were to identify the clinical and epidemiological characteristics of <italic>MERS-CoV</italic>
infection as well as determine its clinical outcome.</p>
</sec>
<sec id="s2"><title>Methods</title>
<p>This was a retrospective-observational study of all laboratory confirmed cases of <italic>MERS-CoV</italic>
infection conducted at the main seven hospitals in the State of Qatar from January, 2012 to April 2018. We used the Fast Track diagnostics real-time reverse-transcription polymerase chain reaction (rRT-PCR), targeting the upE and ORF1a genes respectively. Demographics, clinical information, potential contacts and probable risk factors were collected and analyzed by standard statistical methods.</p>
</sec>
<sec id="s3"><title>Results</title>
<p>The mean annual incidence was 1.7 per 100,0000 person-years. Among the 24 confirmed cases of of <italic>MERS-CoV</italic>
, males constituted the vast majority of cases (23 males) with a median age of 52 years (range 22–74). Fifty percent of the cases were Qatari and 42% reside in the same region. 67% of the cases had contact with camels, and 21% had contact with <italic>MERS-CoV</italic>
-infected patient. Thirty-eight had travel history within 2 weeks of symptoms onset to the Kingdom of Saudi Arabia. Fifty percent were smokers and 42% had comorbidities.</p>
<p>The median symptoms duration was 4.5 days. Most of the patient presented with flu-like symptoms, were fever was the most common presentation, followed by cough, SOB, diarrhea, abdominal pain and headache, 96%, 83%, 33%, 8%, 8% and 4%, respectively. All patients were admitted to a tertiary hospital with a median hospital stay 41 days (8–97). Forty-five percent patients developed severe sepsis with multi-organ failure and needed ICU admission. Fifty percent patients developed acute kidney injury, 29% patients were on hemodialysis and 16% needed extra-corporeal membrane oxygenation. Thirty-three percent patients died. The rest of patients had recovered from the infection and discharged home. Among those who died all had one or more comorbidities.</p>
</sec>
<sec id="s4"><title>Conclusion</title>
<p><italic>MERS-CoV</italic>
infection is a rare infection in the State of Qatar, seen in both Qataris and expatriates with and without travel history. The infection in patients with comorbidities carries high mortality.</p>
</sec>
<sec id="s5"><title>Disclosures</title>
<p><bold>All authors:</bold>
No reported disclosures.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>Qatar</li>
<li>États-Unis</li>
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<region><li>Ohio</li>
</region>
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<name sortKey="Abid, Fatma Ben" sort="Abid, Fatma Ben" uniqKey="Abid F" first="Fatma Ben" last="Abid">Fatma Ben Abid</name>
<name sortKey="Al Khal, Abdullatif" sort="Al Khal, Abdullatif" uniqKey="Al Khal A" first="Abdullatif" last="Al-Khal">Abdullatif Al-Khal</name>
<name sortKey="Al Maslamani, Muna" sort="Al Maslamani, Muna" uniqKey="Al Maslamani M" first="Muna" last="Al- Maslamani">Muna Al- Maslamani</name>
<name sortKey="Alsoub, Hussam" sort="Alsoub, Hussam" uniqKey="Alsoub H" first="Hussam" last="Alsoub">Hussam Alsoub</name>
<name sortKey="Farag, Elmubasher" sort="Farag, Elmubasher" uniqKey="Farag E" first="Elmubasher" last="Farag">Elmubasher Farag</name>
<name sortKey="Ghazouani, Hafedh Ghazouani" sort="Ghazouani, Hafedh Ghazouani" uniqKey="Ghazouani H" first="Hafedh Ghazouani" last="Ghazouani">Hafedh Ghazouani Ghazouani</name>
<name sortKey="Hashim, Samar Mahmoud A" sort="Hashim, Samar Mahmoud A" uniqKey="Hashim S" first="Samar Mahmoud A" last="Hashim">Samar Mahmoud A. Hashim</name>
<name sortKey="Saleh, Mulham Mohed" sort="Saleh, Mulham Mohed" uniqKey="Saleh M" first="Mulham Mohed" last="Saleh">Mulham Mohed Saleh</name>
</country>
<country name="États-Unis"><region name="Ohio"><name sortKey="Dousa, Khalid M" sort="Dousa, Khalid M" uniqKey="Dousa K" first="Khalid M" last="Dousa">Khalid M. Dousa</name>
</region>
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</tree>
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</record>
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